Christopher W Pugh Selected Research

AJM 290

9/2006

Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation.

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Christopher W Pugh Research Topics

Disease

49	Hypoxia (Hypoxemia) 01/2022 - 01/2002
9	Neoplasms (Cancer) 01/2020 - 01/2003
4	Renal Cell Carcinoma (Grawitz Tumor) 11/2010 - 07/2005
2	Infarction (Infarctions) 08/2012 - 07/2006
2	Hereditary leiomyomatosis and renal cell cancer 09/2011 - 10/2010
2	Inflammation (Inflammations) 03/2011 - 02/2011
1	Acute Lung Injury 01/2022
1	Lung Injury 01/2022
1	Paraganglioma (Paragangliomas) 06/2018
1	Hyperglycemia 09/2017
1	Hyperplasia 03/2016
1	Hypotension (Low Blood Pressure) 10/2015
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 04/2012
1	Type 2 Diabetes Mellitus (MODY) 04/2012
1	Diabetic Nephropathies (Diabetic Nephropathy) 04/2012
1	Kidney Diseases (Kidney Disease) 04/2012
1	Kidney Neoplasms (Kidney Cancer) 09/2011
1	Hypersensitivity (Allergy) 06/2011
1	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 02/2011
1	Carcinogenesis 11/2010
1	Leiomyomatosis 11/2010
1	Breast Neoplasms (Breast Cancer) 09/2006
1	Myocardial Infarction 07/2006
1	Ischemia 07/2006
1	Pathologic Processes 02/2003

Drug/Important Bio-Agent (IBA)

29	Oxygen (Dioxygen)IBA 01/2020 - 06/2002
17	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 01/2020 - 04/2003
11	EnzymesIBA 03/2016 - 07/2002
10	Transcription Factors (Transcription Factor)IBA 01/2017 - 08/2002
10	Mixed Function Oxygenases (Monooxygenases)IBA 03/2016 - 07/2002
9	Proteins (Proteins, Gene)FDA Link 01/2020 - 06/2002
6	Protein Isoforms (Isoforms)IBA 06/2018 - 09/2004
3	Ketoglutaric Acids (Ketoglutaric Acid)IBA 11/2017 - 08/2003
3	DioxygenasesIBA 01/2016 - 06/2003
3	Fumarate Hydratase (Fumarase)IBA 09/2011 - 10/2010
3	IronIBA 02/2011 - 08/2003
3	AsparagineIBA 05/2009 - 07/2002
2	Peptides (Polypeptides)IBA 01/2020 - 10/2004
2	Erythropoietin FDA Link 01/2017 - 11/2009
2	OxygenasesIBA 01/2017 - 04/2011
2	HepcidinsIBA 02/2011 - 02/2009
2	UbiquitinIBA 05/2007 - 10/2004
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 06/2002 - 01/2002
1	Macrophage Colony-Stimulating FactorIBA 01/2022
1	Interferon Type IIBA 01/2022
1	PT2385IBA 01/2020
1	Cysteine (L-Cysteine)FDA Link 01/2020
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 06/2018
1	Glucose (Dextrose)FDA LinkGeneric 09/2017
1	Adenosine Triphosphate (ATP)IBA 09/2017
1	Matrix Metalloproteinases (MMPs)IBA 08/2017
1	Cell Adhesion MoleculesIBA 08/2017
1	Amino Acids FDA Link 01/2017
1	Bromodeoxyuridine (BrdU)IBA 03/2016
1	TriazolesIBA 01/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2012
1	Hypoxia-Inducible Factor-Proline DioxygenasesIBA 08/2012
1	GlycogenIBA 08/2012
1	AlbuminsIBA 04/2012
1	Biomarkers (Surrogate Marker)IBA 09/2011
1	ChromatinIBA 06/2011
1	Serine Proteases (Serine Protease)IBA 02/2011
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2010
1	Fumaric aciduriaIBA 11/2010
1	FumaratesIBA 11/2010
1	Myosin-Light-Chain PhosphataseIBA 05/2009
1	Growth Differentiation Factor 15IBA 02/2009
1	Transforming Growth Factor beta (TGF-beta)IBA 02/2009
1	Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA 02/2009
1	CollagenIBA 05/2007
1	Hydroxyproline (4 Hydroxyproline)IBA 05/2007
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2006
1	AJM 290IBA 09/2006
1	DNA (Deoxyribonucleic Acid)IBA 09/2006
1	ThioredoxinsIBA 09/2006
1	LuciferasesIBA 09/2006
1	ElementsIBA 09/2006
1	RNA (Ribonucleic Acid)IBA 09/2006
1	Carbonic Anhydrase IXIBA 09/2006
1	Messenger RNA (mRNA)IBA 07/2006
1	Ribonucleases (Ribonuclease)IBA 07/2006
1	Hypoxia-Inducible Factor 1IBA 07/2005
1	Cell ExtractsIBA 10/2004
1	Ligases (Synthetase)IBA 10/2004
1	Estrogens (Estrogen)FDA Link 09/2004
1	factor AIBA 08/2003
1	dealanylalahopcinIBA 04/2003
1	ProcollagenIBA 04/2003
1	CobaltIBA 07/2002
1	Proline (L-Proline)FDA Link 06/2002

Therapy/Procedure

3	Therapeutics 01/2020 - 09/2006
1	Renal Dialysis (Hemodialysis) 10/2015
1	Aftercare (After-Treatment) 04/2012
1	Ligation 07/2006